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Cilia. 2013 May 31;2(1):7. doi: 10.1186/2046-2530-2-7.

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium.

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  • 1Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands. teunis.j.p.vandam@gmail.com.

Abstract

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.

PMID:
23725226
[PubMed]
PMCID:
PMC3674929
Free PMC Article
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