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Qual Life Res. 2014 Feb;23(1):1-4. doi: 10.1007/s11136-013-0443-4. Epub 2013 May 31.

Don't middle your MIDs: regression to the mean shrinks estimates of minimally important differences.

Author information

  • 1Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK, P.Fayers@abdn.ac.uk.

Abstract

Minimal important differences (MIDs) for patient-reported outcomes (PROs) are often estimated by selecting a clinical variable to serve as an anchor. Then, differences in the clinical anchor regarded as clinically meaningful or important can be used to estimate the corresponding value of the PRO. Although these MID values are sometimes estimated by regression techniques, we show that this is a biased procedure and should not be used; alternative methods are proposed.

PMID:
23722635
[PubMed - indexed for MEDLINE]
PMCID:
PMC3961825
Free PMC Article
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