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J Biol Chem. 2013 Jul 12;288(28):20361-8. doi: 10.1074/jbc.R113.452094. Epub 2013 May 28.

mRNA on the move: the road to its biological destiny.

Author information

  • 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.

Abstract

Cells have evolved to regulate the asymmetric distribution of specific mRNA targets to institute spatial and temporal control over gene expression. Over the last few decades, evidence has mounted as to the importance of localization elements in the mRNA sequence and their respective RNA-binding proteins. Live imaging methodologies have shown mechanistic details of this phenomenon. In this minireview, we focus on the advanced biochemical and cell imaging techniques used to tweeze out the finer aspects of mechanisms of mRNA movement.

KEYWORDS:

3′-UTR; Fluorescence; Gene Expression; In Vivo Imaging; Localization Element/Zipcode; RNA Transport; RNA-Protein Interaction; RNA-binding Proteins; mRNA; β-Actin mRNA

PMID:
23720759
[PubMed - indexed for MEDLINE]
PMCID:
PMC3711302
Free PMC Article
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