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J Biomed Res. 2013 May;27(3):215-9. doi: 10.7555/JBR.27.20130019. Epub 2013 Apr 25.

Genetic variants in pseudogene E2F3P1 confer risk for HBV-related hepatocellular carcinoma in a Chinese population.

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  • 1Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210011, China; ; Department of Hepatobiliary Surgery, Nantong Tumor Hospital, Nantong, Nantong, Jiangsu 226361, China;

Abstract

Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms (SNPs) in E2F3P1 and hepatocellular carcinoma (HCC) risk in 1050 hepatitis B virus (HBV)-positive HCC cases and 1050 chronic HBV carriers. Logistic regression analysis was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC (adjusted OR = 0.66, 95% CIs = 0.51-0.86, P = 0.002) compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 (95% CIs = 1.07-1.86), and the A allele of rs9909601 was significantly associated with HCC risk compared to those with the G allele (adjusted OR = 1.17, 95% CIs = 1.03-1.33, P = 0.017). These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk.

KEYWORDS:

E2F3P1; hepatocellular carcinoma (HCC); single nucleotide polymorphism (SNP); susceptibility

PMID:
23720677
[PubMed]
PMCID:
PMC3664728
Free PMC Article
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