Immune and inflammatory role in renal disease

Compr Physiol. 2013 Apr;3(2):957-76. doi: 10.1002/cphy.c120028.

Abstract

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have anti-inflammatory or immunosuppressive effects in the treatment of renal disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Humans
  • Immunity, Innate
  • Immunologic Factors / therapeutic use*
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Kidney Diseases / drug therapy
  • Kidney Diseases / immunology*

Substances

  • Anti-Inflammatory Agents
  • Immunologic Factors