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Anim Genet. 2013 Dec;44(6):750-3. doi: 10.1111/age.12055. Epub 2013 May 30.

Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle.

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  • 1College of Animal Life Sciences, Kangwon National University, Chuncheon, 200-701, Korea.


The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor-kappa B (NF-κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3'-UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.

© 2013 The Authors, Animal Genetics © 2013 Stichting International Foundation for Animal Genetics.


AKIRIN2 gene; longissimus muscle area; marbling score; single nucleotide polymorphism

[PubMed - indexed for MEDLINE]
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