The clustering of smear-positive tuberculosis in Dabat, Ethiopia: a population based cross sectional study

PLoS One. 2013 May 23;8(5):e65022. doi: 10.1371/journal.pone.0065022. Print 2013.

Abstract

Background: In Ethiopia where tuberculosis epidemic remains high, studies that describe hotspots of the disease are unavailable. This study tried to detect the spatial distribution and clustering of smear-positive tuberculosis cases in Dabat, Ethiopia.

Methods and findings: A population-based cross sectional study conducted in the Dabat Health and Demographic Surveillance System site from October 2010 to September 2011 identified smear-positive tuberculosis cases. Trained field workers collected demographic and location data from each study participant through house-to-house visits. A spatial scan statistic was used to identify purely spatial and space-time clusters of tuberculosis among permanent residents. Two significant (p<0.001) spatial and space-time clusters were identified in the study district.

Conclusion: Tuberculosis is concentrated in certain geographic locations in Dabat, Ethiopia. This kind of clustering can be common in the country, so the National Tuberculosis Control Program can be more effective by identifying such clusters and targeting interventions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Cross-Sectional Studies
  • Epidemiological Monitoring
  • Ethiopia / epidemiology
  • Humans
  • Incidence
  • Prevalence
  • Rural Population
  • Tuberculosis, Pulmonary / epidemiology*
  • Urban Population

Grants and funding

The authors wish to thank the University of Gondar, the AHRI (Armeaur Hansen Research Institute) and TB Care I for funding this study, and the Addis Continental Institute of Public Health for sponsoring the principal investigator doctoral training program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.