Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Chemosphere. 2013 Sep;93(2):217-22. doi: 10.1016/j.chemosphere.2013.04.067. Epub 2013 May 25.

Parental phenols exposure and spontaneous abortion in Chinese population residing in the middle and lower reaches of the Yangtze River.

Author information

  • 1State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.

Abstract

Widespread use of phenols has led to ubiquitous exposure to phenols. In experimental animals, phenols increased resorptions, reduced live litter size and fetal body weights. However, there are limited epidemiological evidences of the relationships between exposure to phenols and pregnancy outcomes. We evaluated the associations between parental urinary levels of various phenols and spontaneous abortion in a Chinese population residing in the middle and lower reaches of the Yangtze River. A case-control study was conducted that included 70 case couples with medically unexplained spontaneous abortion and 180 control couples who did not have a history of spontaneous abortion and had at least one living child. Both parental urinary phenols were measured by ultra-high performance liquid chromatography-tandem mass spectrometry including bisphenol A (BPA), benzophenone-3 (BP-3), 2,3,4-trichlorophenol (2,3,4-TCP), pentachlorophenol (PCP), 4-n-octylphenol (4-n-OP) and 4-n-nonylphenol (4-n-NP). Compared with the low exposure group, there was an increased risk of spontaneous abortion with high paternal urinary PCP concentration [odds ratio (OR)=2.09, 95% Confidence Interval (CI), 1.05-4.14], and maternal exposure to 4-n-OP and alkylphenol(s) also significantly increased the risk of spontaneous abortion (OR=2.21, 95% CI, 1.02-4.80; OR=2.81, 95% CI, 1.39-5.65, respectively). Our study firstly provides the evidence that paternal PCP exposure, maternal 4-n-OP and alkylphenol(s) exposure are associated with spontaneous abortion in humans.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

2,3,4-TCP; 2,3,4-trichlorophenol; 4-n-NP; 4-n-OP; 4-n-Octylphenol; 4-n-nonylphenol; 4-n-octylphenol; APEs; APs; BMI; BP-3; BPA; CI; CR; LODs; ORs; PCP; Parental urinary exposure; Pentachlorophenol; Spontaneous abortion; UPLC–MS/MS; WHO; World Health Organization; alkylphenol polyoxyethylene ethers; alkylphenols; benzophenone-3; bisphenol A; body mass index; confidence interval; creatinine; limits of detection; odds ratios; pentachlorophenol; ultra high performance liquid chromatography-tandem mass spectrometry

PMID:
23714150
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk