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Int J Endocrinol. 2013;2013:534352. doi: 10.1155/2013/534352. Epub 2013 Apr 22.

Serum β -Catenin Levels Associated with the Ratio of RANKL/OPG in Patients with Postmenopausal Osteoporosis.

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  • 1Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.

Abstract

Objective. To demonstrate the role of Wnt/ β -catenin canonical pathway in postmenopausal osteoporosis by evaluating serum β -catenin levels in patients with postmenopausal osteoporosis and analyzing their possible relationship with serum OPG, RANKL, the ratio of RANKL/OPG, sclerostin, and bone turnover markers. Methods. 480 patients with postmenopausal osteoporosis and 170 healthy postmenopausal women were enrolled in the study. Serum β -catenin, OPG, RANKL, and sclerostin levels were measured by enzyme-linked immunosorbent assay. Bone status was assessed by measuring bone mineral density and bone turnover markers. Estradiol levels were also detected. Results. Serum β -catenin levels were lower in postmenopausal osteoporotic women compared to nonosteoporotic postmenopausal women (26.26 ± 14.81 versus 39.33 ± 5.47 pg/mL, P < 0.001). Serum β -catenin was positively correlated with osteoprotegerin (r = 0.232, P < 0.001) and negatively correlated with the ratio of RANKL/OPG, body mass index, and sclerostin (r = -0.128, P = 0.005; r = -0.117, P = 0.010; r = -0.400, P < 0.001, resp.) in patients with postmenopausal osteoporosis. Conclusion. The results indicate that lower serum β -catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis. Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.

PMID:
23710175
[PubMed]
PMCID:
PMC3654357
Free PMC Article

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