Associations of moderate to severe asthma with obstructive sleep apnea

Yonsei Med J. 2013 Jul;54(4):942-8. doi: 10.3349/ymj.2013.54.4.942.

Abstract

Purpose: This study aimed to evaluate the correlation between associating factors of moderate to severe asthma with obstructive sleep apnea (OSA).

Materials and methods: One hundred and sixty-seven patients who visited the pulmonary and sleep clinic in Severance Hospital presenting with symptoms of sleep-disordered breathing were evaluated. All subjects were screened with ApneaLink. Thirty-two subjects with a high likelihood of having OSA were assessed with full polysomnography (PSG).

Results: The mean age was 58.8±12.0 years and 58.7% of subjects were male. The mean ApneaLink apnea-hypopnea index (AHI) was 12.7±13.0/hr. The mean ApneaLink AHI for the 32 selected high risk patients of OSA was 22.3±13.2/hr, which was lower than the sleep laboratory-based PSG AHI of 39.1±20.5/hr. When OSA was defined at an ApneaLink AHI≥5/hr, the positive correlating factors for OSA were age, male gender, and moderate to severe asthma.

Conclusion: Moderate to severe asthma showed strong correlation with OSA when defined at an ApneaLink AHI≥5/hr.

Keywords: Apnea-hypopnea index; ApneaLink; asthma; obstructive sleep apnea; sleep-disordered breathing.

MeSH terms

  • Aged
  • Asthma / complications
  • Asthma / epidemiology
  • Asthma / etiology*
  • Comorbidity
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polysomnography / instrumentation
  • Severity of Illness Index
  • Sleep Apnea Syndromes / epidemiology
  • Sleep Apnea Syndromes / etiology
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / epidemiology
  • Sleep Apnea, Obstructive / physiopathology*