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Zhonghua Wei Chang Wai Ke Za Zhi. 2013 May;16(5):459-62.

[Analysis of treatment and prognosis in 34 patients with anorectal malignant melanoma].

[Article in Chinese]

Author information

  • 1Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, China. duxiaohui301@sina.com.

Abstract

OBJECTIVE:

To explore the prognostic factors of anorectal malignant melanoma (ARMM).

METHODS:

Medical records and follow-up data of 34 patients with ARMM treated in the Chinese PLA General Hospital from March 1993 to November 2011 were analyzed retrospectively.

RESULTS:

There were 26 abdominoperineal resections(APR) and 8 wide local excisions (WLE). Twenty patients underwent postoperative adjuvant therapy, including chemotherapy in 14 cases, radiotherapy in 2 cases, traditional Chinese medicine therapy in 4 cases and immunotherapy in 16 cases. Postoperative follow-up was carried out in all the patients and the mean follow-up period was 27 months. The 1-, 3- and 5-year overall survival rates were 76.3%, 39.6% and 20.6% respectively, while the 1-, 3- and 5-year disease-free survival rates were 60.6%, 30.8% and 12.8% respectively. APR and postoperative immunotherapy could significantly reduce the local recurrence rate. According to the Kaplan-Meier method, gross type of tumor, mural involvement, lymph metastasis, and clinical staging had significant effects on overall survival, while lymph metastasis and postoperative immunotherapy on disease-free survival. Cox proportional hazards model indicated that the clinical staging and postoperative immunotherapy were significant predictive factors.

CONCLUSIONS:

Early diagnosis and correct choice of surgical method are the keys to the treatment. Postoperative immunotherapy can prolong disease-free survival.

PMID:
23696404
[PubMed - in process]
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