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Diabet Med. 2013 Oct;30(10):1225-9. doi: 10.1111/dme.12237. Epub 2013 Jun 21.

Association between KCNQ1 genetic variants and QT interval in a Chinese population.

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  • 1Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai, China.

Abstract

AIM:

There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT-related and diabetes-related variants in KCNQ1 on QT interval in a Chinese population.

METHODS:

We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate-corrected QT interval (QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in KCNQ1 were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped.

RESULTS:

In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation under an additive model (P = 0.0109, empirical P = 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms.

CONCLUSIONS:

Our findings indicate that KCNQ1 is associated with QT interval in a Chinese population with normal glucose regulation.

© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.

PMID:
23692438
[PubMed - indexed for MEDLINE]
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