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Clin Neurophysiol. 2013 Sep;124(9):1737-44. doi: 10.1016/j.clinph.2013.01.030. Epub 2013 May 18.

Gamma activity modulated by picture and auditory naming tasks: intracranial recording in patients with focal epilepsy.

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  • 1Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.

Abstract

OBJECTIVE:

We measured the spatial, temporal and developmental patterns of gamma activity augmented by picture- and auditory-naming tasks and determined the clinical significance of naming-related gamma-augmentation.

METHODS:

We studied 56 epileptic patients (age: 4-56 years) who underwent extraoperative electrocorticography. The picture-naming task consisted of naming of a visually-presented object; the auditory-naming task consisted of answering an auditorily-presented sentence question.

RESULTS:

Naming-related gamma-augmentation at 50-120 Hz involved the modality-specific sensory cortices during stimulus presentation and inferior-Rolandic regions during responses. Gamma-augmentation in the bilateral occipital and inferior/medial-temporal regions was more intense in the picture-naming than auditory-naming task, whereas that in the bilateral superior-temporal, left middle-temporal, left inferior-parietal, and left frontal regions was more intense in the auditory-naming task. Patients above 10 years old, compared to those younger, showed more extensive gamma-augmentation in the left dorsolateral-premotor region. Resection of sites showing naming-related gamma-augmentation in the left hemisphere assumed to contain essential language function was associated with increased risk of post-operative language deficits requiring speech therapy (p < 0.05).

CONCLUSIONS:

Measurement of gamma-augmentation elicited by either naming task was useful to predict postoperative language deficits.

SIGNIFICANCE:

A smaller degree of frontal engagement in the picture-naming task can be explained by no requirement of syntactic processing or less working memory load. More extensive gamma-augmentation in the left dorsolateral-premotor region in older individuals may suggest more proficient processing by the mature brain.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Epilepsy surgery; High-frequency oscillations (HFOs); Intracranial ECoG recording; Language; Outcome; Ripples; Speech

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PMID:
23688918
[PubMed - indexed for MEDLINE]
PMCID:
PMC3735713
Free PMC Article
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