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Org Lett. 2013 Jun 7;15(11):2884-7. doi: 10.1021/ol401239j. Epub 2013 May 20.

Gold(III)-catalyzed three-component coupling reaction (TCC) selective toward furans.

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  • 1School of Pharmaceutical Engineering & Life Sciences, Chang Zhou University, Changzhou, 213164, PR China.


An efficient three-component coupling reaction toward a variety of furan derivatives has been developed. This cascade transformation proceeds via the gold-catalyzed coupling reaction of phenylglyoxal derivatives, secondary amines, and terminal alkynes, under the reaction conditions, that undergoes cyclization into the furan core.

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