Asymmetric transfer hydrogenation of 3-nitroquinolines: facile access to cyclic nitro compounds with two contiguous stereocenters

Xian-Feng Cai; Mu-Wang Chen; Zhi-Shi Ye; Ran-Ning Guo; Lei Shi; Yan-Qin Li; Yong-Gui Zhou

doi:10.1002/asia.201300380

Asymmetric transfer hydrogenation of 3-nitroquinolines: facile access to cyclic nitro compounds with two contiguous stereocenters

Chem Asian J. 2013 Jul;8(7):1381-5. doi: 10.1002/asia.201300380. Epub 2013 May 17.

Authors

Xian-Feng Cai¹, Mu-Wang Chen, Zhi-Shi Ye, Ran-Ning Guo, Lei Shi, Yan-Qin Li, Yong-Gui Zhou

Affiliation

¹ State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.

PMID: 23687053
DOI: 10.1002/asia.201300380

Abstract

Hi, neighbor! The first organocatalyzed asymmetric transfer hydrogenation of aromatic nitro compounds was successfully developed with up to 99 % ee. The new methodology provides a direct and facile access to enantiopure cyclic nitro compounds with two contiguous stereocenters.