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Ann Neurol. 2013 Sep;74(3):490-5. doi: 10.1002/ana.23928. Epub 2013 Sep 4.

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.

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  • 1Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC; Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Abstract

Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury-induced long-term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain.

Copyright © 2013 American Neurological Association.

PMID:
23686636
[PubMed - indexed for MEDLINE]
PMCID:
PMC3791159
Free PMC Article
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