Send to:

Choose Destination
See comment in PubMed Commons below
Cell Biochem Biophys. 2013 Sep;67(1):67-73. doi: 10.1007/s12013-013-9634-4.

Neuronal ubiquitin homeostasis.

Author information

  • 1Department of Neurobiology, Evelyn F. McKnight Institute, Civitan International Research Center, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.


Neurons have highly specialized intracellular compartments that facilitate the development and activity of the nervous system. Ubiquitination is a post-translational modification that controls many aspects of neuronal function by regulating protein abundance. Disruption of this signaling pathway has been demonstrated in neurological disorders such as Parkinson's disease, Amyotrophic Lateral Sclerosis and Angleman Syndrome. Since many neurological disorders exhibit ubiquitinated protein aggregates, the loss of neuronal ubiquitin homeostasis may be an important contributor of disease. This review discusses the mechanisms utilized by neurons to control the free pool of ubiquitin necessary for normal nervous system development and function as well as new roles of protein ubiquitination in regulating the synaptic activity.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk