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Cancer Cell. 2013 May 13;23(5):565-7. doi: 10.1016/j.ccr.2013.04.013.

Luring BRCA1 to the scene of the crime.

Author information

  • Institute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. rb670@columbia.edu

Abstract

To preserve genome stability, BRCA1 must be recruited to sites of DNA damage, where BRCA1 facilitates repair of double-strand DNA breaks (DSBs). In this issue of Cancer Cell, Li and Yu report that BRCA1 recruitment involves a novel interaction between its partner protein BARD1 and poly(ADP-ribose) chains at the DSB.

Copyright © 2013 Elsevier Inc. All rights reserved.

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PMID:
23680142
[PubMed - indexed for MEDLINE]
PMCID:
PMC3746756
Free PMC Article

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