Correlation of oxidative stress parameters and inflammatory markers in tunisian coronary artery disease patients

Azza Dandana; Imen Gammoudi; Salima Ferchichi; Hinda Chahed; Hlima Ben Limam; Faouzi Addad; Abdelhedi Miled

Correlation of oxidative stress parameters and inflammatory markers in tunisian coronary artery disease patients

Int J Biomed Sci. 2011 Mar;7(1):6-13.

Authors

Azza Dandana¹, Imen Gammoudi, Salima Ferchichi, Hinda Chahed, Hlima Ben Limam, Faouzi Addad, Abdelhedi Miled

Affiliation

¹ Department of Clinical Biochemistry, CHU-Farhat Hached, Sousse, Tunisia;

PMID: 23675214
PMCID: PMC3614817

Abstract

Introduction: Oxidative stress is now recognized as being the cause and the consequence of cardiovascular diseases.

Objective: The role that oxidative stress parameters and inflammatory markers may play in diabetes and related cardiovascular disease (CVD) among Tunisian coronary diabetic patients.

Patients and methods: We measured the erythrocyte glutathione peroxidase (GPX), the superoxide dismutase (SOD) activities and the plasmatic total antioxidant status (TAS) concentration by colorimetric methods, the hs-CRP by immunonephelometry assays.

Results: TAS and GPX were significantly decreased among patients compared to the controls (1.14 ± 0.28 mmol/l vs 1.55 ± 0.35 mmol/l; 59.32 ± 10.72 U/gHb vs 149.19 ± 30.95 U/gHb). For the diabetic patients, TAS is correlated positively with hs-CRP (r=0.01, p<10(-3)). At the not diabetic subjects, TAS is correlated negatively with the hsCRP.

Conclusion: Determination of antioxidative defense markers contributes to understanding the effect of stress oxidative on the development and the prevention of cardiovascular disease.

Keywords: cardiovascular diseases; diabetes; glutathione peroxidase (GPX); high sensitivity C reactive protein (hs-CRP); total antioxidant status (TAS).