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World J Gastrointest Surg. 2013 Apr 27;5(4):115-22. doi: 10.4240/wjgs.v5.i4.115.

Effect of Daikenchuto (TJ-100) on abdominal bloating in hepatectomized patients.

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  • 1Kazuhiro Hanazaki, Kengo Ichikawa, Masaya Munekage, Hiroyuki Kitagawa, Ken Dabanaka, Tsutomu Namikawa, Department of Surgery, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.



To evaluate the clinical usefulness of Daikenchuto (DKT) in hepatecomized patients.


Twenty patients were enrolled with informed consent. Two patients were excluded because of cancelled operations. The remaining 18 patients were randomly chosen for treatment with DKT alone or combination therapy of DKT and lactulose (n = 9, each group). Data were prospectively collected. Primary end points were Visual Analogue Scale (VAS) score for abdominal bloating, total Gastrointestinal Symptoms Rating Scale (GSRS) score for abdominal symptoms, and GSRS score for abdominal bloating.


The VAS score for abdominal bloating and total GSRS score for abdominal symptoms recovered to levels that were not significantly different to preoperative levels by 10 d postoperation. Combination therapy of DKT and lactulose was associated with a significantly poorer outcome in terms of VAS and GSRS scores for abdominal bloating, total GSRS score, and total daily calorie intake, when compared with DKT alone therapy.


DKT is a potentially effective drug for postoperative management of hepatectomized patients, not only to ameliorate abdominal bloating, but also to promote nutritional support by increasing postoperative dietary intake.


Abdominal bloating; Daikenchuto; Gastrointestinal symptoms rating scale score; Hepatic resection; Visual analogue scale score

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