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PLoS One. 2013 May 6;8(5):e62140. doi: 10.1371/journal.pone.0062140. Print 2013.

Risk factors of superimposed preeclampsia in women with essential chronic hypertension treated before pregnancy.

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  • 1University Paris 12, CHI Creteil, Creteil, France.

Abstract

OBJECTIVE:

To determine risk factors of superimposed preeclampsia in women with essential chronic hypertension receiving antihypertensive therapy prior to conception.

METHODS:

A retrospective study of 211 patients that analyzed risk factors of superimposed preeclampsia at first prenatal visit. Variables with a p<.1 at univariate analysis were included in a logistic regression analysis. P<.05 was considered as significant.

RESULTS:

Superimposed preeclampsia occurred in 49 (23.2%) women. In logistic regression analysis, previous preeclampsia [OR: 4.05 (1.61-10.16)], and mean arterial blood pressure of 95 mmHg or higher [OR: 4.60 (1.94-10.93)] were associated with increased risk of superimposed preeclampsia. When both variables were present, sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio for superimposed preeclampsia were 43%, 94%, 70%, 85%, and 7.71 (95% CI: 3.20-18.57), respectively.

CONCLUSION:

In essential chronic hypertensive women, previous preeclampsia and mean arterial blood pressure of 95 mmHg or higher are associated with increased risks of superimposed preeclampsia.

PMID:
23671584
[PubMed - indexed for MEDLINE]
PMCID:
PMC3645999
Free PMC Article
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