Send to

Choose Destination
See comment in PubMed Commons below
Clin Neurophysiol. 2013 Aug;124(8):1695-9. doi: 10.1016/j.clinph.2013.02.020. Epub 2013 May 11.

Ultrasound assessment of sural nerve in Charcot-Marie-Tooth 1A neuropathy.

Author information

  • 1Don Carlo Gnocchi Onlus Foundation, Milan, Italy.



Nerve ultrasound (US) has been used to study peripheral nerve disease, and increase of the cross-sectional area (CSA) has been described in demyelinating polyneuropathy. The objective of the current study is to characterise the US features of the sural nerve in a sample of Charcot-Marie-Tooth (CMT) 1A patients.


A total of 20 CMT1A patients were enrolled. As control group we studied 37 age- and sex-matched subjects. All patients underwent clinical examination, neurophysiology and US evaluation of the bilateral sural nerve and right ulnar nerve. US results were correlated with neurophysiology and clinical data.


Sural nerve CSA was not increased in the majority of patients (70%), whereas an increased ulnar nerve CSA was present in the whole sample. Inverse relations were found between CSA of the ulnar nerve and body mass index (BMI) (p<0.0002, R=-0.8) and CSA of the sural nerve and age (right 0.006, R=-0.6, left 0.002, R=-0.6 and left and right p=0.00003, R=-0.4).


US showed ulnar CSA enlargement and normal sural nerve CSA.


The significance of normal sural nerve CSA in CMT1A patients need to be further investigated, possibly through longitudinal studies.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.


Charcot–Marie-Tooth; Sural nerve; Ultrasound assessment

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk