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Korean J Pathol. 2013 Apr;47(2):158-62. doi: 10.4132/KoreanJPathol.2013.47.2.158. Epub 2013 Apr 24.

A solitary fibrous tumor with giant cells in the lacrimal gland: a case study.

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  • 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.


Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.


Giant cells; Lacrimal apparatus; Orbit; Solitary fibrous tumors

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