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Muscle Nerve. 2013 Jun;47(6):909-15. doi: 10.1002/mus.23689. Epub 2013 May 11.

Growth-associated protein-43 expression in cocultures of dorsal root ganglion neurons and skeletal muscle cells with different neurotrophins.

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  • 1Department of Anatomy, Shandong University School of Medicine, 44 Wehua Xi Road, Jinan, Shandong Province 250012, China.

Abstract

INTRODUCTION:

Both target skeletal muscle (SKM) cells and neurotrophins (NTs) are essential for the maintenance of neuronal function and nerve-muscle communication. The effects of different NTs and SKM cells on growth-associated protein-43 (GAP-43) expression in dorsal root ganglion (DRG) neurons have not been clarified.

METHODS:

The morphological relationship between DRG neurons and SKM cells in neuromuscular cocultures was observed by scanning electron microscopy. The levels of GAP-43 and its mRNA were determined after administration of different NTs.

RESULTS:

DRG neurons demonstrated dense neurite outgrowth in the presence of NTs. Distinct NTs promoted GAP-43 and its mRNA expression in neuromuscular cocultures of DRG neurons and SKM cells.

CONCLUSIONS:

These results offer new clues for a better understanding of the effects of distinct NTs on GAP-43 expression in DRG sensory neurons in the presence of target SKM cells and implicate NTs and target SKM cells in DRG neuronal regeneration.

Copyright © 2012 Wiley Periodicals, Inc.

[PubMed - indexed for MEDLINE]
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