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Klin Med (Mosk). 2013;91(1):54-61.

[Predictors of the closure of tuberculosis infiltrate decay cavities during the conservative treatment of infiltrative tuberculosis].

[Article in Russian]


We studied predictors of the closure of tuberculosis infiltrate decay cavities (DC) in the affected regions in patients with infiltrative lung tuberculosis (ILT) by clinical examination. X-ray laboratory and psychological methods 103 patients were under observation for 12 months and received standard therapy. The closure was achieved during the first 4 months in 74 patients but did not occur in 29 ones. Logistic regression analysis showed that the probability of DC closure in the first 4 months decreases in parallel to the initial character of complaints of "chest pain", the size of tuberculosis infiltrates determined in X-ray study, results of thymol test, content of lipid peroxides in expirates, depressive "fatigue" and "suicidal thoughts". The probability of DC cavity during 4 months increased with the initial "number of destructions" in the infiltrate (by X-ray) and depressive "loss of working ability". Results of regression analysis permit to predict the closure of DC during the first 4 months with sensitivity 98.3% and specificity 82.4%.

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