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Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1271-6.

Extracellular matrices of the developing chick retina and cornea. Localization of mRNAs for collagen types II and IX by in situ hybridization.

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  • 1Department of Anatomy and Cellular Biology, Tufts University Health Science Schools, Boston, Massachusetts.


In the embryonic avian eye, the vitreous and the primary corneal stroma are composed in part of collagen types II and IX. Previous biochemical and immunohistochemical studies have suggested that the production of these molecules changes dramatically during development. In the current investigation, we employed in situ hybridization to determine the temporospatial distribution of the messenger ribonucleic acids (mRNAs) for these collagens in the eyes of selected stages of chick embryos. Our observations suggest that through much of development, the ciliary region is the major source for the production of the collagens found within the vitreous. For the cornea, they confirm that both collagen mRNAs are indeed present, and suggest that each is independently regulated.

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