Eur J Pharmacol. 1990 Apr 10;179(1-2):237-40.

Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864.

Marano G, Massotti M, Spagnolo A, Carpi A.

Source

Laboratorio di Farmacologia, Instituto Superiore di Sanità, Roma, Italy.

Abstract

Pretreatment with Ro 5-4864 enhanced the bronchoconstrictor responses to histamine or carbachol in the anaesthetized artificially ventilated guinea pig. This suggests the involvement of a peripheral-type benzodiazepine receptor as also indicated by the lack of effect of clonazepam. PK 11195 did not antagonize the Ro 5-4864-induced enhancement, but itself enhanced the bronchoconstrictor responses to histamine or carbachol. The data indicate that Ro 5-4864 and PK 11195 behave as metactoid sensitizers of histamine or carbachol.

PMID:: 2364987; [PubMed - indexed for MEDLINE]

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