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Epilepsia. 2013 May;54 Suppl 2:80-5. doi: 10.1111/epi.12191.

Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s).

Author information

  • 1Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada. donald.weaver@dal.ca

Abstract

Pharmacoresistant epilepsy is a significant medical problem. The 2nd Halifax International Epilepsy Conference & Retreat identified crucial needs, which if successfully addressed, will aid in paving the way to improved lives for people with pharmacoresistant epilepsy. These are needs: (1) for an evidence-based and dynamic definition of pharmacoresistant epilepsy; (2) for a comprehensive description of the natural history of pharmacoresistant epilepsy; (3) for a comprehensive description of the complications and comorbidities of pharmacoresistant epilepsy; (4) for a rigorous delineation of the epidemiology and socioeconomic impact of pharmacoresistant epilepsy; (5) for clinically meaningful diagnostic and prognostic physiologically based electroencephalography (EEG) biomarkers; (6) for clinically meaningful diagnostic and prognostic anatomically based (MRI Imaging) biomarkers; (7) for biomolecular/biochemical mechanistic understanding of etiopathogenesis for pharmacoresistant epilepsy; (8) for representative animal models of pharmacoresistant epilepsy; (9) for new and effective drugs or other novel treatments for pharmacoresistant epilepsy; and (10) to promote continuing research and research funding targeting pharmacoresistant epilepsy.

Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

PMID:
23646978
[PubMed - indexed for MEDLINE]
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