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Lipids Health Dis. 2013 May 4;12:63. doi: 10.1186/1476-511X-12-63.

Upregulation of triglyceride synthesis in skeletal muscle overexpressing DGAT1.

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  • 1Department of Animal Science, TianJin Agricultural University, TianJin 300384, P.R. China.


The gene encoding diacylglycerol acyltransferase (DGAT1) is a functional and positional candidate gene for milk and intramuscular fat content. A bovine DGAT1 overexpression vector was constructed containing mouse MCK promoter and bovine DGAT1 cDNA. MCK-DGAT1 transgene in FVB mice was researched in present study. The transgene DGAT1 had a high level of expression in contrast to the endogenous DGAT1 in posterior tibial muscle of the transgenic mice, but a low expression level in the cardiac muscle. Compared with wild-type mice, triglyceride and DGAT1 content were approximately fourfold and 50% increased in posterior tibial muscle of the transgenic mice, respectively, while a little increase in cardiac muscle.

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