Abstract
Small molecules inhibit a mutant enzyme confined to tumors, supporting therapeutic approaches that can reprogram metabolism in cancer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Benzeneacetamides / pharmacology*
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Cell Differentiation*
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Cell Transformation, Neoplastic / metabolism*
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Enzyme Inhibitors / pharmacology*
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Glioma / enzymology*
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Glioma / pathology*
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Glutarates / metabolism*
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Hematopoiesis / drug effects*
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Humans
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Imidazoles / pharmacology*
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Isocitrate Dehydrogenase / antagonists & inhibitors
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Isocitrate Dehydrogenase / genetics
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Isocitrate Dehydrogenase / metabolism*
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Leukemia / enzymology*
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Leukemia, Myeloid, Acute / enzymology*
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Phenylurea Compounds / pharmacology*
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Procollagen-Proline Dioxygenase / antagonists & inhibitors*
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Sulfonamides / pharmacology*
Substances
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AGI-5198
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AGI-6780
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Benzeneacetamides
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Enzyme Inhibitors
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Glutarates
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Imidazoles
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Phenylurea Compounds
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Sulfonamides
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IDH2 protein, human
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Isocitrate Dehydrogenase
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IDH1 protein, human
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Procollagen-Proline Dioxygenase