Biochim Biophys Acta. 1990 Jun 14;1044(3):357-60.

Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine.

Bascoul J, Gozé C, Domergue N, Crastes de Paulet A.

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INSERM U.58, Montpellier, France.

Abstract

Serum levels of 7 alpha-hydroxycholesterol (7 alpha (OH)C) were found to increase considerably in hypercholesterolemic patients treated with cholestyramine. After 3-5 days, the normal level, which is in the range of 0.04 mg/l, rose to 1 mg/l. When the treatment was stopped it decreased rapidly with a half-life analogous to that of LDLs. This phenomenon was also observed in non-hypercholesterolemic humans. More than 75% of 7 alpha (OH)C is carried in blood by the LDLs.

PMID:: 2364100; [PubMed - indexed for MEDLINE]

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Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine.

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