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PLoS One. 2013 Apr 26;8(4):e62387. doi: 10.1371/journal.pone.0062387. Print 2013.

Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.

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  • 1Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.

Abstract

BACKGROUND:

Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans.

PRINCIPAL FINDINGS:

The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity.

CONCLUSIONS:

Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.

PMID:
23638060
[PubMed - indexed for MEDLINE]
PMCID:
PMC3637161
Free PMC Article
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