Display Settings:

Format

Send to:

Choose Destination
PLoS One. 2013 Apr 25;8(4):e61613. doi: 10.1371/journal.pone.0061613. Print 2013.

Presence of human papilloma virus in a series of breast carcinoma from Argentina.

Author information

  • 1Department of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.

Abstract

BACKGROUND:

The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer.

METHODS:

Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics.

RESULTS:

The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ(2) test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity.

CONCLUSION:

The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.

PMID:
23637866
[PubMed - indexed for MEDLINE]
PMCID:
PMC3636204
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk