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J Nat Sci Biol Med. 2013 Jan;4(1):160-2. doi: 10.4103/0976-9668.107282.

Comparison of two purification products of shankha bhasma: A prospective randomized control trial.

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  • 1Department of Rasashastra, Vageshwari Ayurvedic College, Karimnagar, Andhra Pradesh, India.

Abstract

BACKGROUND:

Shankha bhasma is widely used in the treatment of gastroesophageal reflux disease (GERD) patients.

AIM:

To compare the efficacy of two purification methods of shankha bhasma in relieving GERD symptoms. In method A, purification was done with lemon juice and method B with sour gruel.

MATERIALS AND METHODS:

Patients with heartburn since at least four days/week but who did undergo endoscopy to assess esophageal mucosa could participate. In this single-phase, single-center, prospective, randomized control trial, the patients were randomized to receive either shankha bhasma purified by method A or by method B. The primary efficacy variable was the proportion of patients with resolution of heartburn at week 4 and week 8.

DESIGN:

Single-phase, single-center, prospective, randomized control trial in a hospital setting.

RESULTS:

Of the total 70 patients who received samples A and B in a randomized double-blind manner, 65% of the patients showed resolution of symptoms in sample A and 28% in sample B at the end of four weeks, whereas, 71% of the patients showed resolution of symptoms in sample A and 31% in sample B at the end of eight weeks; P value was statistically significant for resolution of symptoms (P <0.005).

CONCLUSION:

Purification of shankha bhasma by lemon juice method is better than sour gruel method in terms of clinical outcome in GERD patients and is hence recommended.

KEYWORDS:

Gastroesophageal reflux disease; lemon juice; purification; shankha bhasma; sour gruel

PMID:
23633854
[PubMed]
PMCID:
PMC3633269
Free PMC Article
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