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J Magn Reson Imaging. 2014 Feb;39(2):377-86. doi: 10.1002/jmri.24150. Epub 2013 Apr 30.

Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance.

Author information

  • 1Vanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA; Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Neurology, Vanderbilt School of Medicine, Nashville, Tennessee, USA; Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA.

Abstract

PURPOSE:

To evaluate how flow territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain's ability to respond to age-related changes in brain function. These patterns have been investigated in cerebrovascular disease; however, here we evaluated how flow-territory asymmetry related to memory generally in older adults.

MATERIALS AND METHODS:

A multi-faceted MRI protocol, including vessel-encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD-Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n = 15; age = 64.5 ± 7 years) and age-matched mild cognitive impairment volunteers (MCI; n = 7; age = 62.7 ± 3.7 years).

RESULTS:

An inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (P = 0.04), which reversed in MCI volunteers (P = 0.04). No relationship was found between memory performance and cortical tissue volume in either group (P > 0.05). Group-level differences for HC volunteers performing above versus below average on CERAD-I were observed for flow territory asymmetry (P < 0.02) and cortical volume (P < 0.05) only.

CONCLUSION:

Findings suggest that flow territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

ageing; cerebral blood flow; dementia; flow territory asymmetry; memory; vessel encoded arterial spin labeling (VE-ASL)

PMID:
23633160
[PubMed - indexed for MEDLINE]
PMCID:
PMC3735670
Free PMC Article
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