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Magn Reson Med. 2014 Mar;71(3):1075-81. doi: 10.1002/mrm.24769.

Ultrashort echo time bi-component analysis of cortical bone--a field dependence study.

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  • 1Department of Radiology, University of California, San Diego, California, USA; Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai, People's Republic of China; Yancheng Medical College, Jiangsu, People's Republic of China.

Abstract

PURPOSE:

The purpose of this study is to investigate the effect of differing field strength on the T2* of cortical bone at 1.5 T and 3 T.

METHODS:

Ultrashort echo time pulse sequences were used to study six bovine and nine human bone samples at 1.5 T and 3 T using single- and bi-component T2* analysis.

RESULTS:

On average, the bound water T2* of bovine bone decreased by 16% (from 0.32 ms at 1.5 T to 0.27 ms at 3 T, P < 0.01) and the bound water T2* of human bone decreased by 21% (from 0.42 ms at 1.5 T to 0.33 ms at 3 T, P < 0.01) at the higher field strength. The free water T2* of bovine bone decreased by 50% (from 4.23 ms at 1.5 T to 2.12 ms at 3 T, P < 0.001) and the free water T2* of human bone decreased by 68% (from 7.65 ms at 1.5 T to 2.46 ms at 3 T, P < 0.001) at the higher field strength. Bound and free water fractions showed only minor change with field strength in bovine (< 2%, P > 0.05) and human bone (< 4%, P > 0.05).

CONCLUSION:

Ultrashort echo time bi-component analysis provides consistent bound and free water fractions at 1.5 T and 3 T, thereby allowing field-independent comparisons.

Copyright © 2013 Wiley Periodicals, Inc.

PMID:
23630048
[PubMed - in process]
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