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Pharm Biol. 2013 Jul;51(7):856-62. doi: 10.3109/13880209.2013.767840. Epub 2013 Apr 29.

Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats.

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  • 1Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.

Abstract

CONTEXT:

Daucus carota Linn (Apiaceae), a useful vegetable, is traditionally used in treating kidney and hepatic dysfunctions.

OBJECTIVE:

To evaluate the protective and curative potential of D. carota root extract on renal ischemia reperfusion injury in rats.

MATERIALS AND METHODS:

Wistar rats were selected with 8 + 8 groups (n = 6). Renal pedicles of rats were occluded for 45 min and allowed for reperfusion period. In protective and curative studies, 14 days prior and 14 days after the induction of ischemia/reperfusion (I/R), rats received petroleum ether extract (PEE 250 and 500 mg/kg), fractional methanol extract (FME 250 and 500 mg/kg) and direct methanol extract (DME 250 and 500 mg/kg) of Daucus carota root, orally, once daily.

RESULTS:

PEE at a dose of 500 mg/kg significantly (p < 0.001) reduced the levels of serum creatinine (0.853-3.090 mg/dl), uric acid (1.300-3.500 mg/dl) and urea (58.26-132.00 mg/dl) compared to disease control. FME at a dose of 500 mg/kg body weight significantly (p < 0.001) reduced the levels of serum creatinine (0.960-3.090 mg/dl), uric acid (1.700-3.500 mg/dl) and urea (77.17-132.00 mg/dl) compared to disease control. DME at a dose of 500 mg/kg body weight significantly (p < 0.001) reduced the levels of serum creatinine (1.173-3.090 mg/dl), uric acid (2.267-3.500 mg/dl) and urea (84.75-132.00 mg/dl) compared to disease control.

DISCUSSION AND CONCLUSION:

Findings demonstrate that postconditioning with the D. carota root extract significantly improves kidney function in I/R rats.

PMID:
23627465
[PubMed - indexed for MEDLINE]
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