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Zhong Yao Cai. 2012 Oct;35(10):1674-9.

[Preparation of sustained release microspheres containing oxymatrine and their release characteristics in vitro].

[Article in Chinese]

Author information

  • 1School of Pharmacy, Guiyang Medical University, Guiyang 550004, China. 352380337@qq.com

Abstract

OBJECTIVE:

To prepare poly(lactide-co-glycolide) (PLGA) microspheres containing Oxymatrine (OMT-PLGA-MS) and study their release characteristics in vitro.

METHODS:

OMT-PLGA-MS was prepared with PLGA as carriers using double emulsion solvent evaporation method (W/O/W). The preparation technology of microspheres was optimized by orthogonal design, and the microspheres were characterized in terms of morphology, the rate of drug loading, encapsulation efficiency, and in vitro drug release.

RESULTS:

The formed microspheres were spherical with smooth surfaces and the average size was (98.3 +/- 3.4) microm. The encapsulation efficiency and rate of drug loading were (70.14 +/- 3.47)% and (21.59 +/- 1.07)%, respectively. In vitro release study revealed that 84.63% of OMT was released from OMT-PLGA-MS in 240 hours, and the Higuchi model fitted OMT release pattern best.

CONCLUSION:

OMT-PLGA-MS is prepared successfully and shows good sustained release characteristics.

PMID:
23627137
[PubMed - indexed for MEDLINE]
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