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Eur J Inorg Chem. 2012 Apr;2012(12):2099-2107.

Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.

Author information

  • 1Departments of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Rd., Evanston, IL 60208, USA.

Abstract

A bacteria-targeted MR contrast agent, Zn-1, consisting of two Zn-dipicolylamine (Zn-dpa) groups conjugated to a GdIII chelate has been synthesized and characterized. In vitro studies with S. aureus and E. coli show that Zn-1 exhibits a significant improvement in bacteria labeling efficiency vs. control. Studies with a structural analogue, Zn-2, indicate that removal of one Zn-dpa moiety dramatically reduces the agent's affinity for bacteria. The ability of Zn-1 to significantly reduce the T 1 of labeled vs. unlabeled bacteria, resulting in enhanced MR image contrast, demonstrates its potential for visualizing bacterial infections in vivo.

KEYWORDS:

Bacteria labeling; Imaging agents; Magnetic resonance imaging; Medicinal chemistry; Zinc

PMID:
23626484
[PubMed]
PMCID:
PMC3634600
Free PMC Article
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