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Psychiatry Res. 2013 Aug 30;209(1):110-3. doi: 10.1016/j.psychres.2013.03.035. Epub 2013 Apr 23.

Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits.

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  • 1Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu 740, Edifício Leitao da Cunha, 1° Andar, CEP 04023-900 Sao Paulo, Brazil. vanessakaota@gmail.com

Abstract

We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Cognition; Executive functions; Gene

PMID:
23623450
[PubMed - indexed for MEDLINE]
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