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Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):2981-6. doi: 10.1016/j.msec.2013.03.022. Epub 2013 Mar 24.

Synthesis of hydroxyapatite nanotubes for biomedical applications.

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  • 1Materials Chemistry Group, Department of Chemical Sciences, Tata Institute of Fundamental Research, Dr. Homi Bhabha Road, Colaba, Mumbai 400 005, India.


Single phase, stoichiometrically pure, hollow nanotubes of hydroxyapatite have been synthesized and single-particle analysis has been performed to successfully prove the sole formation of Ca10(PO4)6(OH)2 phase. The facile synthesis involves a sol-gel process under neutral conditions in the presence of a sacrifical anodic alumina template. The structures formed are hollow nanotubes that have been characterized by XRD, SEM, TEM, SAED, EELS, EDS and BET measurements. The diameter of the resulting tubes is in the range of 140-350 nm, length is on the order of a few microns and the wall thickness of the tubes was found to be ca. 30 nm. Moreover these tubes had a large BET surface area of 115 m(2)/g and were found to be biocompatible. They displayed inertness in the presence of NIH 3T3 mouse fibroblast cells as dictated by an MTT assay.

Copyright © 2013 Elsevier B.V. All rights reserved.

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