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Cell. 2013 Apr 25;153(3):516-9. doi: 10.1016/j.cell.2013.04.003.

The long and short of microRNA.

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  • 1Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Abstract

MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is controlled by highly developed regulatory pathways and fine-tuning mechanisms both affecting miRNA processing and altering mature miRNA target specificity.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23622238
[PubMed - indexed for MEDLINE]
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