Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Neurosci. 2013 Nov;123(11):752-8. doi: 10.3109/00207454.2013.798733. Epub 2013 Aug 1.

Effects of uncoupling protein 2 -866G/A polymorphism on platelet reactivity and prognosis in Chinese patients with type 2 diabetes and ischemic stroke.

Author information

  • 11Department of Anatomy Histology and Pharmacology, State Key Laboratory of Pharmaceutical Biotechnology, Laboratory of Neuropharmacology, School of Life Sciences, Nanjing University , Nanjing , China.

Abstract

The purpose of this study was to assess the effects of -866G>A polymorphism of mitochondrial uncoupling protein 2 (UCP-2) on platelet reactivity and prognosis in patients with type 2 diabetes and ischemic stroke (IS). A total of 405 Chinese patients with type 2 diabetes and stroke were assessed in a 4-year follow-up case-control study. Patient response to antiplatelet therapy was measured with the Platelet Function Analyzer-100 by means of collagen/adenosine diphosphate (CADP) and collagen/epinephrine (CEPI) cartridges. The primary end point was a composite of stroke and TIA (transient ischemic attack), the secondary end point was death. The -866G>A polymorphism in UCP-2 was genotyped by TaqMan MGB probe method. The -866G>A SNP in UCP-2 was not significantly associated with recurrence of diabetic ischemical stroke (p = 0.57). A significant trend toward nonfull response to antiplatelet therapy was seen in patients carrying A allel in comparison with those carrying GG genotype, as shown by the CADP and CEPI tests (p < 0.0001). Our 4-year follow-up study shows no association between -866G>A variant of UCP-2 in type 2 diabetes and the risk of developing stroke. But in conclusion, the A allel is associated with clopidogrel resistance.

PMID:
23621569
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Informa Healthcare
    Loading ...
    Write to the Help Desk