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J Am Chem Soc. 2013 May 15;135(19):7090-3. doi: 10.1021/ja401273g. Epub 2013 Apr 30.

Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.

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  • 1Department of Chemistry, School of Medicine, University of California, Riverside, California 92521, USA.


A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.

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