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West Indian Med J. 2012 Oct;61(7):665-9.

Extracellular superoxide dismutase, a potential extracellular biomarker candidate for prolactinoma.

Author information

  • 1Section of Neurosurgery, First Affiliated Hospital of Baotou Medical College, Inner Mongolia, China. jh_bt@163.com

Abstract

AIM:

To investigate whether the extracellular superoxide dismutase (EC-SOD) and manganese superoxide dismutase (Mn-SOD) level changes during prolactinoma (PRL) development.

METHODS:

Surgical tissues from 37 female patients with PRL were tested for Mn-SOD and serum samples from such PRL patients were tested for EC-SOD level changes with Western Blot. The MnSOD level from blood cells was also investigated to show whether the Mn-SOD variation could locate tumorigenesis tissues.

RESULTS:

According to the patients' age analysis, age 20-40 years is high risk for getting PRL. There is a positive relationship between the PRL severity and EC-SOD. The Mn-SOD level from surgical tissues, but not blood cells, also shows a corresponding positive relationship to PRL severity, which indicates that elevated Mn-SOD might only happen in PRL tumorigenesis tissues.

CONCLUSIONS:

Extracellular superoxide dismutase is an extracellular protein and the serum EC-SOD could be a good candidate for the diagnoses of prolactinoma.

PMID:
23620962
[PubMed - indexed for MEDLINE]
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