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Am J Hematol. 2013 Jul;88(7):606-11. doi: 10.1002/ajh.23463. Epub 2013 May 30.

Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma.

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  • 1Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Yale University School of Public Health, New Haven, Connecticut.

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

Copyright © 2013 Wiley Periodicals, Inc.

PMID:
23619945
[PubMed - indexed for MEDLINE]
PMCID:
PMC3902049
Free PMC Article
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