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Angew Chem Int Ed Engl. 2013 Jun 3;52(23):6047-9. doi: 10.1002/anie.201300258. Epub 2013 Apr 24.

The absolute configuration of (+)- and (-)-erythro-mefloquine.

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  • 1Max-Planck-Institut für Biophysikalische Chemie, Department of NMR-Based Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany.


The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, whereas the configuration determined by three enantioselective syntheses is wrong.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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