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Clin Endosc. 2013 Mar;46(2):138-46. doi: 10.5946/ce.2013.46.2.138. Epub 2013 Mar 31.

Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy.

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  • 1Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.


Among early colorectal carcinoma, endoscopic treatment is generally indicative for cases with intramucosal to submucosal (SM) superficial invasion, because cases with SM deep invasion should be treated surgically due to the risk of lymph node metastasis. It is important, therefore, to distinguish between superficial and deep SM invasion in early colorectal carcinoma prior to treatment. In this review we assessed the clinical usefulness and knack of pit pattern and narrow band imaging (NBI) diagnosis using magnifying observation. VN type pit pattern, type C3 in NBI Hiroshima classification and NBI type 3 in NBI international colorectal endoscopic (NICE) classification are useful predictors of SM deep invasion. In NBI magnifying observation evaluation of both the vascular pattern and surface pattern are important. We have to use pit pattern diagnosis and NBI magnifying diagnosis as the situation demands with the knowledge of both advantage and disadvantage in each diagnostic method.


Colorectal subumucosal carcinoma; Invasion depth; Magnifying colonoscopy; Narrow band imaging; Pit pattern

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