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PLoS One. 2013 Apr 16;8(4):e61783. doi: 10.1371/journal.pone.0061783. Print 2013.

CT air trapping is independently associated with lung function reduction over time.

Author information

  • 1Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. metsonno@gmail.com

Abstract

PURPOSE:

We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.

MATERIALS AND METHODS:

Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function.

RESULTS:

We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p<0.001). CT air trapping further elicits accelerated loss of FEV1/FVC (additional 0.24% reduction per percent increase; pā€Š=ā€Š0.014).

CONCLUSION:

In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC.

PMID:
23613934
[PubMed - indexed for MEDLINE]
PMCID:
PMC3628859
Free PMC Article
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