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Sci Rep. 2013;3:1699. doi: 10.1038/srep01699.

On-chip cytometry using plasmonic nanoparticle enhanced lensfree holography.

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  • 1Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA.

Abstract

Computational microscopy tools, in particular lensfree on-chip imaging, provide a large field-of-view along with a long depth-of-field, which makes it feasible to rapidly analyze large volumes of specimen using a compact and light-weight on-chip imaging architecture. To bring molecular specificity to this high-throughput platform, here we demonstrate the use of plasmon-resonant metallic nanoparticles to automatically recognize different cell types based on their plasmon-enhanced lensfree holograms, detected and reconstructed over a large field-of-view of e.g., ~24 mm².

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